In our Pediatric Weight Clinic in Calgary we check in all patients a HbA1C level. Essentially we are trying to see what the risk is for that patient to get Diabetes.
A recent study in Diabetes Care looked at the usefulness of the HbA1C. If it is over 6.5% it is highly specific. However some doctors prefer to use a glucose tolerance test.
Here is a copy of the study(Sourced out of Health Day News)
HbA1c ≥6.5 Percent Is Specific, Not Sensitive for T1DM
Across four studies, HbA1c ≥6.5 percent specific, but not sensitive, early indicator of T1DM in youth
FRIDAY, Aug. 31 (HealthDay News) — Using a glycated hemoglobin (HbA1c) threshold of ≥6.5 percent is a specific but not sensitive early indicator of type 1 diabetes (T1D) in high-risk children and young adults, according to a study published in the September issue of Diabetes Care.
Kendra Vehik, Ph.D., of the University of South Florida in Tampa, and colleagues examined the utility of HbA1c as an alternative criterion for impaired glucose tolerance (IGT) or T1D in high-risk individuals younger than 21 years. Participants were recruited from four prospective studies and included 884 participants from Type 1 Diabetes TrialNet Natural History; 587 from Diabetes Prevention Trial-Type 1; 420 from Trial to Reduce IDDM in the Genetically at Risk; and 91 from The Environmental Determinants of Diabetes in the Young. All participants had an HbA1c within 90 days of an oral glucose tolerance test (OGTT) and a two-hour plasma glucose measure.
The researchers found that using HbA1c of ≥5.7 percent as an indicator of IGT resulted in a very low sensitivity across the studies (8 to 42 percent) and variable specificity (64 to 95 percent). Sensitivity was very low (24 to 34 percent) and specificity high (98 to 99 percent) using HbA1c of ≥6.5 percent as a threshold for T1D. Across the four studies, the positive predictive value of HbA1c varied from 50 to 94 percent.
“HbA1c ≥6.5 percent is a specific but not sensitive early indicator for T1D in high-risk subjects <21 years of age diagnosed by OGTT or asymptomatic hyperglycemia,” the authors write. “Redefining the HbA1c threshold is recommended if used as an alternative criterion in diagnosing T1D.”